RESEARCH
Research
Tool Development
Unraveling the “here and now” of biological activity with nucleic acid sensors
We are developing technologies that utilize nucleic acids with molecular recognition capabilities, such as aptamers and riboswitches, to detect the “where” and “when” of specific molecules in living systems in real time. This enables the visualization of dynamic biological phenomena that were previously difficult to capture, providing new analytical approaches for understanding the mechanisms underlying dynamic biological processes.
Pharmaceutical development
RNA hackingがもたらす新しい薬の可能性
私たちが開発した「RNA hacking」は、標的mRNAの立体構造を人為的に変化させ、タンパク質翻訳を制御する革新的な技術です。この機構は既存の核酸医薬が抱える課題を克服する次世代型の薬の基盤となり得ます。副作用を抑えつつ標的遺伝子の機能を選択的に制御することで、これまで治療困難だった疾患への新たなアプローチが期待されています。
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Increase protein levels!
The RNA hacking we are developing is a technology that can change the shape of target mRNA. Using this technology, we are developing treatments for diseases that are caused by a deficiency of essential proteins for life.
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Reduce protein levels!
RNA hacking, a technology we are developing, can alter the shape of target mRNAs. We are using this technology to research ways to reduce the amount of disease-causing proteins.